Second reproductive dysfunction caused by background reasons (HG)in men.
Standard testosterone (T)
Alternative treatment improves metabolic parameters but results in infertility.
Objective to evaluate cromifen (CC)
Treatment of male obese adult male
Related hypogonads (MOSH). DesignSingle-
Center, random, doubleblind, placebo-
Control test.
Participants 70-
Eight men aged 365u2009±u20097.
The body mass index is 8 years (BMI)
> 201730 kg/m2, total testosterone (TT)
≤ 300ng ng/dL and symptoms in the ADAM questionnaire.
A randomized allocation of 50 mg CC or placebo was accepted (PLB)for 12 weeks. Outcomes(1)
Clinical features: ADAM and sexuality questionnaire; (2)
Hormone profile: serum TT, Free T, estrogen (E2)
, Promoting progesterone (LH), follicle-
Stimulating hormone (FSH)
And sex hormones
Bound immunoglobulin (SHBG); (3)
Body composition: Analysis of BMI, waist circumference and bioelectrical impedance; (4)
Metabolic spectrum: blood pressure, fasting blood glucose, HbA1c, insulin, insulin-
IR and lipid profile; (5)
Vascular endothelial function
Mediated expansion of arm arteries, quantitative evaluation of endothelial ancestral cells and serum sICAM-1, sVCAM-1. select vegetarian-sE levels; (6)
Safety: red blood cell pressure, serum prostate-
Specific Antigen, International Prostate Symptom Score and self-score
Adverse effects of the report.
Results one sexual complaint was improved (
Weak erection; Pu2009