KISSTOY
Risk factors for rectal lymphogranuloma venereum in gay men: results of a multicentre case-control study in the UK
by:KISSTOY
2021-05-14
Abstract: objective to investigate the risk factors of rectal lymph cyst. rLGV)
In men who have sex with men (MSM). Design A case-
A comparative study of men having sex with rLGV in 6 hospitals in Britaincases)with rLGV-
Negative control: male without potential rLGV symptoms (CGa)
In addition, men who have such symptoms have sex with men (CGs).
Methods there were 90 cases of rLGV, 74 cases of recruited and 69 cases of CGs, accounting for 2008 ~ 2010.
It is reported that in the past 3 months, the lifestyle and sexual behavior of using the internetbased computer-assisted self-interviews.
Logistic regression was used to analyze the factors associated with rLGV.
As a result, cases are more likely to be infected with HIV-positive (89%)
With CGa (46%)and CGs (64%).
The independent Behavioral Risk of RLGV is: unprotected receptive anal sex (adjusted OR (AOR)10. 7, 95% CI 3. 5to 32. 8)
Kill another (AOR=6. 7, CI 1. 8 to 25. 3)
, Under the influence of gamma rays
Dingone (AOR=3. 1, CI 1. 3 to 7. 4)
And anonymous contact (AOR=2. 7, CI 1. 2 to 6. 3)
Bihai Patrol Department;
No protection is inserted into anal sex (AOR=4. 7, CI 2. 0 to 10. 9)
Rectal Flushing (AOR=2. 9 CI 1. 3 to 6. 6)
Compared to CGs.
The incubation period for symptoms exposed to 30 days was shown.
Conclusion unprotected accepted anal intercourse is a key risk factor for rectal LGV, and rectal-to-
In places where inserted anal sex also occurs, rectal transmission is easy.
The association between HIV and rLGV seems to be related to HIV-
Active men seek unprotected sex with others with the same HIV status, sex and drug interests.
Frequent sexually transmitted infections screening and intervention should be carried out for these men to minimize the associated risks.
Objective to investigate the risk factors of rectal lymph swelling. rLGV)
In men who have sex with men (MSM).
Design A case-
A comparative study of men having sex with rLGV in 6 hospitals in Britaincases)with rLGV-
Negative control: male without potential rLGV symptoms (CGa)
In addition, men who have such symptoms have sex with men (CGs).
Methods there were 90 cases of rLGV, 74 cases of recruited and 69 cases of CGs, accounting for 2008 ~ 2010.
It is reported that in the past 3 months, the lifestyle and sexual behavior of using the internetbased computer-assisted self-interviews.
Logistic regression was used to analyze the factors associated with rLGV.
As a result, cases are more likely to be infected with HIV-positive (89%)
With CGa (46%)and CGs (64%).
The independent Behavioral Risk of RLGV is: unprotected receptive anal sex (adjusted OR (AOR)10. 7, 95% CI 3. 5to 32. 8)
Kill another (AOR=6. 7, CI 1. 8 to 25. 3)
, Under the influence of gamma rays
Dingone (AOR=3. 1, CI 1. 3 to 7. 4)
And anonymous contact (AOR=2. 7, CI 1. 2 to 6. 3)
Bihai Patrol Department;
No protection is inserted into anal sex (AOR=4. 7, CI 2. 0 to 10. 9)
Rectal Flushing (AOR=2. 9 CI 1. 3 to 6. 6)
Compared to CGs.
The incubation period for symptoms exposed to 30 days was shown.
Conclusion unprotected accepted anal intercourse is a key risk factor for rectal LGV, and rectal-to-
In places where inserted anal sex also occurs, rectal transmission is easy.
The association between HIV and rLGV seems to be related to HIV-
Active men seek unprotected sex with others with the same HIV status, sex and drug interests.
Frequent sexually transmitted infections screening and intervention should be carried out for these men to minimize the associated risks.
An outbreak of sexual lymph swellingLGV)
Affecting men who have sex with men (MSM)
It has been recognized since 2003.
Cases were subsequently reported in Western Europe, North America and other countries in Australia.
LGV is a sexually transmitted infection (STI)
By L-
Chlamydia serum (Ct)
While routine Ct tests can detect LGV, additional subtypes are required to identify a specific LGV serum.
As many countries do not have access to this resource, our global understanding of this infection is limited.
Where tested and monitored, consistent features of LGV infection in men who have sex with men have been observed.
Most of them are HIV-
Positive men with a reported serum positive rate of 58-100%, 5, and 6 were frequently infected with homosexuality and other sexually transmitted infections.
Most cases are characterized by acute rectal syndrome, and a few cases are characterized by anal ulcers or ulcers in the groin/urethriform syndrome.
However, LGV subtypes are usually performed only for men with symptomatic Ct straight Yin inflammation, 10 leading to concerns that a groin and asymptomatic rectal infection may be missed.
It is reported that there are also symptoms and asymptomatic throat LGV infections. 11Case-
A survey of men who had sex with men at the sex care clinic found that the rate of rectal infection in LGV was from 0. 2%12 to 1.
2%, the proportion of asymptomatic cases increased from 7 to 13 in 5% to 27%.
7 in the study of test Ct, LGV infection in the urinary and reproductive system was rarely found
Positive urethra sample
From 2008 to 341, a retrospective test was conducted on a sample of 2010 male sex men diagnosed with rectal LGV in Amsterdam, and 2% patients were found to have both urinary LGV, inindex)
Of the cases, 7% were urinary LGV.
Of the eight previous risk factors Studies, 2 examined the clinic records 14, 15, but there was no conclusion on sexual behavior.
A survey including a patient questionnaire found that LGV straight officer inflammation and anal enema use in men who have sex with men and high
Risk of having sex
Despite ten years of observation, many clinical and epidemiology questions remain unanswered: given the significant imbalance between rectal and genital infections, what is the exact pattern and risk of transmission?
To what extent does behavioral or biological susceptibility explain the observed high levels of HIV co-infection?
We did a case.
In order to further explore the risk factors of LGV acquisition, a comparative study was conducted.
Prospective Multi-center case of study design-
From August 2008 to December 2010, a control study was conducted at the Department of Urology medicine, HIV and specialists (
(Such as gay men)
Clinics in six hospitals in London, Brighton and Glasgow.
The center was selected according to high LGV cases.
Open all availableaccess, free-of-
Responsible for the examination and treatment of sexually transmitted infections.
The study was approved by the National Ethics Council (07/H0712/156)
And obtain the patient\'s personal informed consent.
The subjects were enrolled in the case of rectal LGV (rLGV).
For each case recruited at the participating center, in the same week as the case, the comparison was sought from qualified patients attending the same clinic, but in other respects unmatched.
Eligibility for control includes reporting unmarried sex with another man within the last 3 months and being recognized as rLGV negative.
Two controls were recruited in each case: symptomatic (CGs)
There are potential symptoms of rLGV (
Anal or ulcer)
No symptoms, no potential rLGV symptoms (CGa).
To objectify straight officer inflammation or ulcer, a straight officer mirror examination was performed on all subjects with rectal symptoms, unless there was a clinical taboo, or if the patient refused.
Clinical examination and STI screening according to local clinical protocol. Ct-
Positive samples are used by the reference laboratory of sexually transmitted bacteria or the Scottish bacterial transmission infection laboratory LGV-specific real-Time PCR analysis.
Prospective Multi-center case of study design-
From August 2008 to December 2010, a control study was conducted at the Department of Urology medicine, HIV and specialists (
(Such as gay men)
Clinics in six hospitals in London, Brighton and Glasgow.
The center was selected according to high LGV cases.
Open all availableaccess, free-of-
Responsible for the examination and treatment of sexually transmitted infections.
The study was approved by the National Ethics Council (07/H0712/156)
And obtain the patient\'s personal informed consent.
The subjects were enrolled in the case of rectal LGV (rLGV).
For each case recruited at the participating center, in the same week as the case, the comparison was sought from qualified patients attending the same clinic, but in other respects unmatched.
Eligibility for control includes reporting unmarried sex with another man within the last 3 months and being recognized as rLGV negative.
Two controls were recruited in each case: symptomatic (CGs)
There are potential symptoms of rLGV (
Anal or ulcer)
No symptoms, no potential rLGV symptoms (CGa).
To objectify straight officer inflammation or ulcer, a straight officer mirror examination was performed on all subjects with rectal symptoms, unless there was a clinical taboo, or if the patient refused.
Clinical examination and STI screening according to local clinical protocol. Ct-
Positive samples are used by the reference laboratory of sexually transmitted bacteria or the Scottish bacterial transmission infection laboratory LGV-specific real-Time PCR analysis.
17 data collection
The reported patient data object completes the computer-assisted self-Interview (CASI)
In the private space of the clinic, or by email, a link to the survey is provided for the family to complete.
CASI was designed using Snap Survey software and deployed using the Snap webhost service certified by ISO/IEC 27001.
The clinic assigned a study number;
No personally identifiable information was requested.
The issue explores the history of social demographics, HIV and sexually transmitted infections detection over the last 3 months, detailed sexual behavior, alcohol and substance use, prior knowledge of LGV and related health promotion, and
Asked about the details of the events that might have infected the LGV and asked about those cases that thought they could identify the infection.
The average completion time is 20 min.
Of the 261 patients who participated in the study and tested rectal Ct/LGV, the 233 patients Survey was returned (89%).
The clinic\'s loss of Internet access and time constraints, as well as the failure of those who chose to send links via email to complete CASI at home, resulted in a shortage of patient surveys.
The total recruitment response rate for the study was 84% (
Case 78%, CGa 88%, CGs 87%).
Clinicians reported clinical data through the network, including demographics, symptoms at presentation, details of STI screening tests performed, prescribed treatment, History of HIV and STI tests, and contact tracking results
Report based.
The data from these surveys are matched with the patient survey by the study number.
Statistical analysis data is analyzed using Stata 12.
19 consecutive variables were initially explored using t-test.
Little data is missing (
In men who have sex with men (MSM). Design A case-
A comparative study of men having sex with rLGV in 6 hospitals in Britaincases)with rLGV-
Negative control: male without potential rLGV symptoms (CGa)
In addition, men who have such symptoms have sex with men (CGs).
Methods there were 90 cases of rLGV, 74 cases of recruited and 69 cases of CGs, accounting for 2008 ~ 2010.
It is reported that in the past 3 months, the lifestyle and sexual behavior of using the internetbased computer-assisted self-interviews.
Logistic regression was used to analyze the factors associated with rLGV.
As a result, cases are more likely to be infected with HIV-positive (89%)
With CGa (46%)and CGs (64%).
The independent Behavioral Risk of RLGV is: unprotected receptive anal sex (adjusted OR (AOR)10. 7, 95% CI 3. 5to 32. 8)
Kill another (AOR=6. 7, CI 1. 8 to 25. 3)
, Under the influence of gamma rays
Dingone (AOR=3. 1, CI 1. 3 to 7. 4)
And anonymous contact (AOR=2. 7, CI 1. 2 to 6. 3)
Bihai Patrol Department;
No protection is inserted into anal sex (AOR=4. 7, CI 2. 0 to 10. 9)
Rectal Flushing (AOR=2. 9 CI 1. 3 to 6. 6)
Compared to CGs.
The incubation period for symptoms exposed to 30 days was shown.
Conclusion unprotected accepted anal intercourse is a key risk factor for rectal LGV, and rectal-to-
In places where inserted anal sex also occurs, rectal transmission is easy.
The association between HIV and rLGV seems to be related to HIV-
Active men seek unprotected sex with others with the same HIV status, sex and drug interests.
Frequent sexually transmitted infections screening and intervention should be carried out for these men to minimize the associated risks.
Objective to investigate the risk factors of rectal lymph swelling. rLGV)
In men who have sex with men (MSM).
Design A case-
A comparative study of men having sex with rLGV in 6 hospitals in Britaincases)with rLGV-
Negative control: male without potential rLGV symptoms (CGa)
In addition, men who have such symptoms have sex with men (CGs).
Methods there were 90 cases of rLGV, 74 cases of recruited and 69 cases of CGs, accounting for 2008 ~ 2010.
It is reported that in the past 3 months, the lifestyle and sexual behavior of using the internetbased computer-assisted self-interviews.
Logistic regression was used to analyze the factors associated with rLGV.
As a result, cases are more likely to be infected with HIV-positive (89%)
With CGa (46%)and CGs (64%).
The independent Behavioral Risk of RLGV is: unprotected receptive anal sex (adjusted OR (AOR)10. 7, 95% CI 3. 5to 32. 8)
Kill another (AOR=6. 7, CI 1. 8 to 25. 3)
, Under the influence of gamma rays
Dingone (AOR=3. 1, CI 1. 3 to 7. 4)
And anonymous contact (AOR=2. 7, CI 1. 2 to 6. 3)
Bihai Patrol Department;
No protection is inserted into anal sex (AOR=4. 7, CI 2. 0 to 10. 9)
Rectal Flushing (AOR=2. 9 CI 1. 3 to 6. 6)
Compared to CGs.
The incubation period for symptoms exposed to 30 days was shown.
Conclusion unprotected accepted anal intercourse is a key risk factor for rectal LGV, and rectal-to-
In places where inserted anal sex also occurs, rectal transmission is easy.
The association between HIV and rLGV seems to be related to HIV-
Active men seek unprotected sex with others with the same HIV status, sex and drug interests.
Frequent sexually transmitted infections screening and intervention should be carried out for these men to minimize the associated risks.
An outbreak of sexual lymph swellingLGV)
Affecting men who have sex with men (MSM)
It has been recognized since 2003.
Cases were subsequently reported in Western Europe, North America and other countries in Australia.
LGV is a sexually transmitted infection (STI)
By L-
Chlamydia serum (Ct)
While routine Ct tests can detect LGV, additional subtypes are required to identify a specific LGV serum.
As many countries do not have access to this resource, our global understanding of this infection is limited.
Where tested and monitored, consistent features of LGV infection in men who have sex with men have been observed.
Most of them are HIV-
Positive men with a reported serum positive rate of 58-100%, 5, and 6 were frequently infected with homosexuality and other sexually transmitted infections.
Most cases are characterized by acute rectal syndrome, and a few cases are characterized by anal ulcers or ulcers in the groin/urethriform syndrome.
However, LGV subtypes are usually performed only for men with symptomatic Ct straight Yin inflammation, 10 leading to concerns that a groin and asymptomatic rectal infection may be missed.
It is reported that there are also symptoms and asymptomatic throat LGV infections. 11Case-
A survey of men who had sex with men at the sex care clinic found that the rate of rectal infection in LGV was from 0. 2%12 to 1.
2%, the proportion of asymptomatic cases increased from 7 to 13 in 5% to 27%.
7 in the study of test Ct, LGV infection in the urinary and reproductive system was rarely found
Positive urethra sample
From 2008 to 341, a retrospective test was conducted on a sample of 2010 male sex men diagnosed with rectal LGV in Amsterdam, and 2% patients were found to have both urinary LGV, inindex)
Of the cases, 7% were urinary LGV.
Of the eight previous risk factors Studies, 2 examined the clinic records 14, 15, but there was no conclusion on sexual behavior.
A survey including a patient questionnaire found that LGV straight officer inflammation and anal enema use in men who have sex with men and high
Risk of having sex
Despite ten years of observation, many clinical and epidemiology questions remain unanswered: given the significant imbalance between rectal and genital infections, what is the exact pattern and risk of transmission?
To what extent does behavioral or biological susceptibility explain the observed high levels of HIV co-infection?
We did a case.
In order to further explore the risk factors of LGV acquisition, a comparative study was conducted.
Prospective Multi-center case of study design-
From August 2008 to December 2010, a control study was conducted at the Department of Urology medicine, HIV and specialists (
(Such as gay men)
Clinics in six hospitals in London, Brighton and Glasgow.
The center was selected according to high LGV cases.
Open all availableaccess, free-of-
Responsible for the examination and treatment of sexually transmitted infections.
The study was approved by the National Ethics Council (07/H0712/156)
And obtain the patient\'s personal informed consent.
The subjects were enrolled in the case of rectal LGV (rLGV).
For each case recruited at the participating center, in the same week as the case, the comparison was sought from qualified patients attending the same clinic, but in other respects unmatched.
Eligibility for control includes reporting unmarried sex with another man within the last 3 months and being recognized as rLGV negative.
Two controls were recruited in each case: symptomatic (CGs)
There are potential symptoms of rLGV (
Anal or ulcer)
No symptoms, no potential rLGV symptoms (CGa).
To objectify straight officer inflammation or ulcer, a straight officer mirror examination was performed on all subjects with rectal symptoms, unless there was a clinical taboo, or if the patient refused.
Clinical examination and STI screening according to local clinical protocol. Ct-
Positive samples are used by the reference laboratory of sexually transmitted bacteria or the Scottish bacterial transmission infection laboratory LGV-specific real-Time PCR analysis.
Prospective Multi-center case of study design-
From August 2008 to December 2010, a control study was conducted at the Department of Urology medicine, HIV and specialists (
(Such as gay men)
Clinics in six hospitals in London, Brighton and Glasgow.
The center was selected according to high LGV cases.
Open all availableaccess, free-of-
Responsible for the examination and treatment of sexually transmitted infections.
The study was approved by the National Ethics Council (07/H0712/156)
And obtain the patient\'s personal informed consent.
The subjects were enrolled in the case of rectal LGV (rLGV).
For each case recruited at the participating center, in the same week as the case, the comparison was sought from qualified patients attending the same clinic, but in other respects unmatched.
Eligibility for control includes reporting unmarried sex with another man within the last 3 months and being recognized as rLGV negative.
Two controls were recruited in each case: symptomatic (CGs)
There are potential symptoms of rLGV (
Anal or ulcer)
No symptoms, no potential rLGV symptoms (CGa).
To objectify straight officer inflammation or ulcer, a straight officer mirror examination was performed on all subjects with rectal symptoms, unless there was a clinical taboo, or if the patient refused.
Clinical examination and STI screening according to local clinical protocol. Ct-
Positive samples are used by the reference laboratory of sexually transmitted bacteria or the Scottish bacterial transmission infection laboratory LGV-specific real-Time PCR analysis.
17 data collection
The reported patient data object completes the computer-assisted self-Interview (CASI)
In the private space of the clinic, or by email, a link to the survey is provided for the family to complete.
CASI was designed using Snap Survey software and deployed using the Snap webhost service certified by ISO/IEC 27001.
The clinic assigned a study number;
No personally identifiable information was requested.
The issue explores the history of social demographics, HIV and sexually transmitted infections detection over the last 3 months, detailed sexual behavior, alcohol and substance use, prior knowledge of LGV and related health promotion, and
Asked about the details of the events that might have infected the LGV and asked about those cases that thought they could identify the infection.
The average completion time is 20 min.
Of the 261 patients who participated in the study and tested rectal Ct/LGV, the 233 patients Survey was returned (89%).
The clinic\'s loss of Internet access and time constraints, as well as the failure of those who chose to send links via email to complete CASI at home, resulted in a shortage of patient surveys.
The total recruitment response rate for the study was 84% (
Case 78%, CGa 88%, CGs 87%).
Clinicians reported clinical data through the network, including demographics, symptoms at presentation, details of STI screening tests performed, prescribed treatment, History of HIV and STI tests, and contact tracking results
Report based.
The data from these surveys are matched with the patient survey by the study number.
Statistical analysis data is analyzed using Stata 12.
19 consecutive variables were initially explored using t-test.
Little data is missing (